Can we give more than 4 serum types of one vaccine (IB) on the first day of the bird’s life?

Dr. Milad Ibrahim Uraibi

We can give more than one weakened serum strain of the same vaccine strain on the first day of the bird’s life, as an immune response will be formed for each serum strain, and the evidence for this is that when examining by PCR technology at the age of 5 days, we will find that the serum strain is present in the bird’s body, meaning that the virus has been replicated while entering the body, and we can also do a challenge with the weakened virus given at the age of 14 days and see that the bird is not infected or that the infection is small or weak.

The cilia hypertrophy in the bronchial region and the viral load CT and anatomical signs can be measured as a standard for chicks that were vaccinated on the first day.

 

It can be vaccinated with more than one type or serum strain of one strain, and it is very safe, but mixing is not permissible unless there is approval from the US Food and Drug Administration (FAD) or the company has mixed the vaccine according to the experiments conducted by the company and the type of materials on which the vaccine is loaded (adjuvants). There may be positives in mixing according to the experiments or they may be negative.

 

The important note that everyone should know is that the process of combining more than one serum strain of the same strain, meaning a multi-variant vaccine, will target the same local lymphocytes close to the site of vaccine entry, and therefore the more targeting of those glands, the stronger the immune response process.

There is a saying that multiple vaccines will weaken the immune system or what is called (use up) immune system. But on the contrary, it will work to create a strong immune response and also increase the bird’s challenge to many challenges it faces in the hall.

As for the immunity formed by giving a multi-variety vaccine, it is called (active immunity).

Immune responses are often classified into: –

1- Pro-inflammatory immune response.

2- Pro-allergic immune response.

3- Anti-inflammatory immune response.

 

The classification of these responses depends on specific effects in the bird’s body, all of which makes it difficult to understand the inflammatory process that precedes the formation of the immune response, so it cannot be said that the immune response is the actual result of the inflammatory process resulting from the vaccination process.

 

When a multi-dose vaccine of a particular vaccine strain is given, complex processes will occur at the site of administration and two types of T cells will be identified, the first type is Th1, which are cells that regulate delayed hypersensitivity reactions and are pro-inflammatory as mentioned above (hypersensitivity).

The second type is Th2 as a regulator of the allergic and anti-inflammatory response.

 

As for the CD4 group, it works in two ways, supporting or anti-inflammatory (orchestra) as I explained in a previous lecture.

 

These cells will divide to make a single serum strike and start working equally according to the conditions and controls of the bird’s immune system, where each cell will work completely isolated from the other cells, i.e. branches in a laboratory until the immune response is formed from zero signal to 3 signal, and according to the mechanism of work and the strength of the immune system and the health of the bird.

 

This division of work is called (immune homeostasis). Vaccines are manufactured, designed and combined by the ideas of scientists, many experiments, approvals and researchers.

 

The immune system recognizes multiple antigens in a single vaccine and then draws a picture of these antigens. This mechanism is known as (correspondence). The bird’s immune system mounts an appropriate immune response that includes an ongoing immune dialogue with the antigens. Thus, at the end of this process and after crossing signal 3, the intensity of the immune response will be determined by the type, strength and level of the antigen (vaccine virus) entering the bird’s body. Therefore, vaccines are designed to contain an optimal level and a good type of antigen, to form an immune response that matches and is specifically designed for the vaccine strain given to the bird before the bird’s body removes the antigen from it.

 

Giving multiple antigens to one type of vaccine will stimulate the immune system, especially for the respiratory system, but it does not lead to tissue damage, because it is a weakened antigen, unlike the live and natural virus.

 

Therefore, the multiple antigens in the vaccine will not be (cytokine storm) and will not cause any immune response to the bird.

 

Conclusion:

1- More than one antigen (for the IB vaccine strain) can be given on the first day.

2- Mixing these vaccines must be done according to the manufacturer and according to FAD instructions.

3- Give a multi-antigen vaccine only in areas where this antigen is prevalent.

4- Rely on the experiments conducted by researchers (Masters and PhD) in the process of mixing these vaccines.